Safety range of free valproic acid serum concentration in adult patients
نویسندگان
چکیده
منابع مشابه
Effect of UGT2B7 genetic variants on serum valproic acid concentration.
OBJECTIVE To investigate the effect of UGT2B7 A268G and UGT2B7 G211T genetic polymorphism on serum drug concentration of valproic acid (VPA). METHODS Genetic polymorphisms of UGT2B7 A268G and UGT2B7 G211T were tested in 248 epileptic patients by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Data including basic information, epilepsy type, times and doses of dr...
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Objective(s) As there are conflicting findings regarding the clearance-dose and patient characteristics relationships for valproic acid (VPA), this study was conducted to investigate the relationship between patient demographic characteristics, VPA dosage and the drug clearance in adult Iranian patients. Materials and Methods Patients (N= 47) were either on monotherapy with VPA or were under co...
متن کاملValproic acid-induced pancreatitis in an adult.
Ribeirão Preto School of Medicine, University of São Paulo, São Paulo SP, Brazil: Physician Resident in Neurology, Department of Neurosciences and Behaviour Sciences; Neurologist and Associated Professor, Department of Neurosciences and Behaviour Sciences; Emergencist Physician, Departament of Internal Medicine. Idiosyncratic reactions to drugs are adverse effects not straightly related with ph...
متن کاملSafety and efficacy of valproic acid preparations.
BACKGROUND Rising of the cost of drug therapy is one of the most notable negative tendencies of modern medicine. The main reasons for this trend are the increased costs for preclinical and clinical phases of drug development. Reproduction of drugs after cessation of patent protection is much less costly. Replacement of the original (reference) drug to generics would greatly reduce the cost of d...
متن کاملTotal and Free Serum Sialic Acid Concentration in Liver Diseases
BACKGROUND The objective of this study was to compare the levels of total (TSA) and free (FSA) sialic acid in acute and chronic liver diseases. MaTERIALS AND METHODS: The serum TSA and FSA levels were determined in 278 patients suffering from acute and chronic liver diseases of different etiologies. TSA was estimated by enzymatic method and FSA by the thiobarbituric method modified by Skoza and...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2020
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0238201